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Table 2 List of 604 preferred terms used to identify AEs for adjudication

From: Retrospective analysis of arterial occlusive events in the PACE trial by an independent adjudication committee

Preferred term (MEdDRA 21.0)

Acute aortic syndrome


Pituitary infarction

Acute coronary syndrome

Directional Doppler flow tests abnormal

Placental infarction

Acute myocardial infarction

Dissecting coronary artery aneurysm

Pneumatic compression therapy

Administration site thrombosis

Disseminated intravascular coagulation

Poor peripheral circulation

Adrenal thrombosis

Disseminated intravascular coagulation in newborn

Popliteal artery entrapment syndrome


Dry gangrene

Portal shunt procedure



Portal vein cavernous transformation

Amaurosis fugax

ECG electrically inactive area

Portal vein occlusion


ECG signs of myocardial infarction

Portal vein stenosis

Angina pectoris

ECG signs of myocardial ischaemia

Portal vein thrombosis

Angina unstable

Electrocardiogram Q wave abnormal

Portosplenomesenteric venous thrombosis

Anginal equivalent

Electrocardiogram ST segment abnormal

Post angioplasty restenosis

Angiogram abnormal

Electrocardiogram ST segment depression

Post cardiac arrest syndrome

Angiogram cerebral abnormal

Electrocardiogram ST segment elevation

Post procedural myocardial infarction

Angiogram peripheral abnormal

Electrocardiogram ST-T segment abnormal

Post procedural pulmonary embolism


Electrocardiogram ST-T segment depression

Post procedural stroke


Electrocardiogram ST-T segment elevation

Post stroke depression

Anterior segment ischaemia

Electrocardiogram T wave abnormal

Post thrombotic syndrome

Aortic arteriosclerosis

Electrocardiogram T wave inversion

Posthaemorrhagic hydrocephalus

Aortic bypass

Electrocardiogram U wave inversion

Postinfarction angina

Aortic embolus

Embolia cutis medicamentosa

Postoperative thrombosis

Aortic occlusion

Embolic cerebral infarction

Postpartum thrombosis

Aortic restenosis

Embolic pneumonia

Postpartum venous thrombosis

Aortic stenosis

Embolic stroke

Precerebral arteriosclerosis

Aortic surgery


Precerebral artery occlusion

Aortic thrombosis

Embolism arterial

Precerebral artery thrombosis

Aortogram abnormal

Embolism venous

Prinzmetal angina




Application site thrombosis

Exercise electrocardiogram abnormal

Prosthetic vessel implantation

Arm amputation

Exercise test abnormal

Pulmonary artery occlusion


External counterpulsation

Pulmonary artery stenosis

Arterectomy with graft replacement

Extremity necrosis

Pulmonary artery therapeutic procedure

Arterial bypass occlusion

Extrinsic iliac vein compression

Pulmonary artery thrombosis

Arterial bypass operation

Femoral artery embolism

Pulmonary embolism

Arterial bypass stenosis

Finger amputation

Pulmonary endarterectomy

Arterial bypass thrombosis

Foetal cerebrovascular disorder

Pulmonary infarction

Arterial disorder

Foot amputation

Pulmonary microemboli

Arterial graft


Pulmonary thrombosis

Arterial insufficiency

Gastrointestinal ischaemia

Pulmonary tumour thrombotic microangiopathy

Arterial occlusive disease

Glomerular vascular disorder

Pulmonary vein occlusion

Arterial restenosis

Graft ischaemia

Pulmonary vein stenosis

Arterial stenosis

Graft thrombosis

Pulmonary veno-occlusive disease

Arterial stent insertion

Haemorrhage coronary artery

Pulmonary venous thrombosis

Arterial therapeutic procedure

Haemorrhagic adrenal infarction


Arterial thrombosis

Haemorrhagic cerebral infarction


Arteriogram abnormal

Haemorrhagic infarction

Raynaud's phenomenon

Arteriogram carotid abnormal

Haemorrhagic stroke

Renal arteriosclerosis

Arteriogram coronary abnormal

Haemorrhagic transformation stroke

Renal artery angioplasty

Arteriogram renal abnormal

Haemorrhagic vasculitis

Renal artery arteriosclerosis


Haemorrhoids thrombosed

Renal artery occlusion

Arteriosclerosis coronary artery

Hand amputation

Renal artery stenosis

Arteriosclerosis Monckeberg type


Renal artery thrombosis

Arteriosclerotic gangrene


Renal embolism

Arteriosclerotic retinopathy


Renal infarct

Arteriospasm coronary

Heparin-induced thrombocytopenia

Renal ischaemia


Hepatic artery embolism

Renal vascular thrombosis

Arteriovenous fistula occlusion

Hepatic artery occlusion

Renal vein embolism

Arteriovenous fistula thrombosis

Hepatic artery stenosis

Renal vein occlusion

Arteriovenous graft site stenosis

Hepatic artery thrombosis

Renal vein thrombosis

Arteriovenous graft thrombosis

Hepatic infarction

Retinal artery embolism


Hepatic ischaemia

Retinal artery occlusion

Artificial blood vessel occlusion

Hepatic vascular thrombosis

Retinal artery stenosis


Hepatic vein embolism

Retinal artery thrombosis

Atherosclerotic plaque rupture

Hepatic vein occlusion

Retinal infarction

Atrial appendage closure

Hepatic vein stenosis

Retinal ischaemia

Atrial thrombosis

Hepatic vein thrombosis

Retinal vascular disorder

Axillary vein thrombosis

Homans' sign positive

Retinal vascular occlusion

Balint's syndrome

Hypothenar hammer syndrome

Retinal vascular thrombosis

Basal ganglia infarction

Hypoxic–ischaemic encephalopathy

Retinal vein occlusion

Basal ganglia stroke

Iliac artery disease

Retinal vein thrombosis

Basilar artery occlusion

Iliac artery embolism

Reversible cerebral vasoconstriction syndrome

Basilar artery stenosis

Iliac artery occlusion

Reversible ischaemic neurological deficit

Basilar artery thrombosis

Iliac vein occlusion

Right hemisphere deficit syndrome

Biliary ischaemia

Implant site thrombosis

Scan myocardial perfusion abnormal

Blindness transient

Incision site vessel occlusion

Shunt occlusion

Blood creatine phosphokinase abnormal


Shunt thrombosis

Blood creatine phosphokinase increased

Inferior vena cava syndrome

SI QIII TIII pattern

Blood creatine phosphokinase MB abnormal

Inferior vena caval occlusion

Silent myocardial infarction

Blood creatine phosphokinase MB increased

Infusion site thrombosis

Skin ulcer

Bone infarction

Injection site thrombosis

Soft tissue necrosis

Bone marrow ischaemia

Inner ear infarction

Spinal artery embolism

Brachial artery entrapment syndrome

Instillation site thrombosis

Spinal artery thrombosis

Brachiocephalic arteriosclerosis

Intermittent claudication

Spinal cord infarction

Brachiocephalic artery occlusion

Interscapulothoracic amputation

Spinal cord ischaemia

Brachiocephalic artery stenosis

Intestinal infarction

Spinal vascular disorder

Brachiocephalic vein occlusion

Intestinal ischaemia

Splenic artery stenosis

Brachiocephalic vein stenosis

Intra-aortic balloon placement

Splenic artery thrombosis

Brachiocephalic vein thrombosis

Intracardiac mass

Splenic embolism

Brain hypoxia

Intracardiac thrombus

Splenic infarction

Brain stem embolism

Intracranial artery dissection

Splenic thrombosis

Brain stem infarction

Intracranial venous sinus thrombosis

Splenic vein occlusion

Brain stem ischaemia

Intraoperative cerebral artery occlusion

Splenic vein thrombosis

Brain stem stroke


Spontaneous amputation

Brain stem thrombosis

Ischaemic cardiomyopathy

Stoma site thrombosis

Budd–Chiari syndrome

Ischaemic cerebral infarction

Stress cardiomyopathy

Capsular warning syndrome

Ischaemic contracture of the left ventricle

Stress echocardiogram abnormal

Cardiac arrest

Ischaemic enteritis

Stroke in evolution

Cardiac discomfort

Ischaemic gastritis

Subclavian artery embolism

Cardiac stress test abnormal

Ischaemic heart disease prophylaxis

Subclavian artery occlusion

Cardiac ventricular scarring

Ischaemic hepatitis

Subclavian artery stenosis

Cardiac ventricular thrombosis

Ischaemic limb pain

Subclavian artery thrombosis

Cardiopulmonary exercise test abnormal

Ischaemic mitral regurgitation

Subclavian coronary steal syndrome

Cardio-respiratory arrest

Ischaemic nephropathy

Subclavian steal syndrome

Cardiovascular disorder

Ischaemic neuropathy

Subclavian vein occlusion

Cardiovascular insufficiency

Ischaemic pancreatitis

Subclavian vein stenosis

Carotid angioplasty

Ischaemic skin ulcer

Subclavian vein thrombosis

Carotid arterial embolus

Ischaemic stroke

Subendocardial ischaemia

Carotid arteriosclerosis

Jugular vein occlusion

Superior mesenteric artery syndrome

Carotid artery bypass

Jugular vein thrombosis

Superior sagittal sinus thrombosis

Carotid artery calcification

Kounis syndrome

Superior vena cava occlusion

Carotid artery disease

Lacunar infarction

Superior vena cava syndrome

Carotid artery insufficiency

Lacunar stroke

Surgical vascular shunt

Carotid artery occlusion

Lateral medullary syndrome

Testicular infarction

Carotid artery restenosis

Leg amputation

Thalamic infarction

Carotid artery stenosis

Leriche syndrome


Carotid artery stent insertion

Limb amputation

Thromboangiitis obliterans

Carotid artery stent removal

Limb traumatic amputation


Carotid artery thrombosis

Macular ischaemia


Carotid endarterectomy

Mahler sign


Carotid revascularisation

May–Thurner syndrome

Thrombophlebitis migrans

Catheter site thrombosis

Medical device site thrombosis

Thrombophlebitis neonatal

Catheterisation venous

Mesenteric arterial occlusion

Thrombophlebitis superficial

Cavernous sinus thrombosis

Mesenteric arteriosclerosis

Thrombosed varicose vein

Central pain syndrome

Mesenteric artery embolism


Central venous catheterisation

Mesenteric artery stenosis

Thrombosis corpora cavernosa

Cerebellar artery occlusion

Mesenteric artery stent insertion

Thrombosis in device

Cerebellar artery thrombosis

Mesenteric artery thrombosis

Thrombosis mesenteric vessel

Cerebellar embolism

Mesenteric phlebosclerosis

Thrombosis prophylaxis

Cerebellar infarction

Mesenteric vascular insufficiency

Thrombotic cerebral infarction

Cerebellar ischaemia

Mesenteric vascular occlusion

Thrombotic microangiopathy

Cerebellar stroke

Mesenteric vein thrombosis

Thrombotic stroke

Cerebral arteriosclerosis

Mesenteric venous occlusion

Thrombotic thrombocytopenic purpura

Cerebral artery embolism


Thyroid infarction

Cerebral artery occlusion

Microvascular coronary artery disease

Toe amputation

Cerebral artery restenosis

Migrainous infarction

Tongue infarction

Cerebral artery stenosis

Millard–Gubler syndrome

Transient ischaemic attack

Cerebral artery thrombosis


Transverse sinus thrombosis

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy


Troponin I increased

Cerebral congestion

Moyamoya disease

Troponin increased

Cerebral gas embolism

Myocardial hypoxia

Troponin T increased

Cerebral hypoperfusion

Myocardial infarction

Truncus coeliacus thrombosis

Cerebral infarction

Myocardial ischaemia

Tumour embolism

Cerebral infarction foetal

Myocardial necrosis

Tumour thrombosis

Cerebral ischaemia

Myocardial necrosis marker increased

Ultrasonic angiogram abnormal

Cerebral microembolism

Myocardial reperfusion injury

Ultrasound Doppler abnormal

Cerebral reperfusion injury

Myocardial stunning

Umbilical cord occlusion

Cerebral revascularisation


Umbilical cord thrombosis

Cerebral septic infarct

Necrosis ischaemic

Uterine ischaemia

Cerebral small vessel ischaemic disease


Vaccination site thrombosis

Cerebral thrombosis

NIH stroke scale abnormal

Vascular access site occlusion

Cerebral vascular occlusion

NIH stroke scale score decreased

Vascular access site thrombosis

Cerebral vasoconstriction

NIH stroke scale score increased

Vascular encephalopathy

Cerebral venous thrombosis

Non-cardiac chest pain

Vascular graft

Cerebrospinal thrombotic tamponade

Obstetrical pulmonary embolism

Vascular graft occlusion

Cerebrovascular accident

Obstructive shock

Vascular graft restenosis

Cerebrovascular accident prophylaxis

Ocular ischaemic syndrome

Vascular graft stenosis

Cerebrovascular disorder

Ocular vascular disorder

Vascular graft thrombosis

Cerebrovascular insufficiency

Omental infarction

Vascular insufficiency

Cerebrovascular operation

Ophthalmic vein thrombosis

Vascular occlusion

Cerebrovascular stenosis

Optic ischaemic neuropathy

Vascular operation

Chest discomfort

Optic nerve infarction

Vascular pseudoaneurysm thrombosis

Chest pain

Ovarian vein thrombosis

Vascular shunt

Choroidal infarction

Paget–Schroetter syndrome

Vascular skin disorder

Choroidal sclerosis

Pancreatic infarction

Vascular stenosis

Claudication of jaw muscles

Papillary muscle infarction

Vascular stent insertion


Paradoxical embolism

Vascular stent occlusion

Coeliac artery occlusion


Vascular stent restenosis

Coeliac artery stenosis

Paraneoplastic thrombosis

Vascular stent stenosis

Colitis ischaemic


Vascular stent thrombosis

Collateral circulation



Compression garment application



Computerised tomogram coronary artery abnormal

Pelvic venous thrombosis

Vasodilation procedure

Coronary angioplasty

Penetrating atherosclerotic ulcer

Vena cava embolism

Coronary arterial stent insertion

Penile artery occlusion

Vena cava filter insertion

Coronary artery bypass

Penile vein thrombosis

Vena cava filter removal

Coronary artery compression

Percutaneous coronary intervention

Vena cava thrombosis

Coronary artery disease

Perinatal stroke

Venogram abnormal

Coronary artery dissection

Peripheral arterial occlusive disease

Venoocclusive disease

Coronary artery embolism

Peripheral arterial reocclusion

Venoocclusive liver disease

Coronary artery insufficiency

Peripheral artery angioplasty

Venous angioplasty

Coronary artery occlusion

Peripheral artery bypass

Venous occlusion

Coronary artery reocclusion

Peripheral artery occlusion

Venous operation

Coronary artery restenosis

Peripheral artery restenosis

Venous recanalisation

Coronary artery stenosis

Peripheral artery stenosis

Venous repair

Coronary artery surgery

Peripheral artery stent insertion

Venous stenosis

Coronary artery thrombosis

Peripheral artery thrombosis

Venous stent insertion

Coronary brachytherapy

Peripheral coldness

Venous thrombosis

Coronary bypass stenosis

Peripheral embolism

Venous thrombosis in pregnancy

Coronary bypass thrombosis

Peripheral endarterectomy

Venous thrombosis limb

Coronary endarterectomy

Peripheral ischaemia

Venous thrombosis neonatal

Coronary no-reflow phenomenon

Peripheral revascularisation

Vertebral artery occlusion

Coronary ostial stenosis

Peripheral vascular disorder

Vertebral artery stenosis

Coronary revascularisation

Periprocedural myocardial infarction

Vertebral artery thrombosis

Coronary vascular graft occlusion


Vertebrobasilar insufficiency

Coronary vascular graft stenosis


Vessel puncture site occlusion

Coronary vein stenosis


Vessel puncture site thrombosis

Deep vein thrombosis


Vestibular ischaemia

Deep vein thrombosis postoperative


Visceral venous thrombosis

Delayed ischaemic neurological deficit


Visual acuity reduced transiently

Dependent rubor


Visual agnosia

Device embolisation


Visual midline shift syndrome

Device occlusion


Wall motion score index abnormal

Device related thrombosis


Diabetic macroangiopathy


Diabetic microangiopathy


Diabetic vascular disorder