Fig. 1
From: RNA demethylase ALKBH5 in cancer: from mechanisms to therapeutic potential
Dynamic regulation of N6-methyladenosine (m6A) and structure of RNA demethylase ALKBH5. a The m6A modification is added to the RNA by the methyltransferase complex (writer) composed of the METTL3-METTL14 heterodimer core subunit and additional cofactors such as WTAP. The RNA m6A modification could be removed by RNA demethylases (erasers), FTO and ALKBH5 in a reversible manner. b Domain structures of ALKBH5. c Cartoon representation of the ALKBH566–292 structure (PDB ID: 4NJ4) in complex with Mn(II) [67]. Mn(II) is a substitute for Fe(II). d Schematic form of the ALKBH566–292 structure [67]. Arrows represent β-strands and circles represent α-helices. The DSBH is highlighted in yellow, the extra loop (β9-10 loop) in purple and the NRLs in red