Fig. 5
From: RNA demethylase ALKBH5 in cancer: from mechanisms to therapeutic potential
Potential approaches for ALKBH5 targeting in cancers. a Small-molecule inhibitors of ALKBH5. b Proteolysis targeting chimera (PROTAC) for ALKBH5 protein degradation. c CRISPR-based site-specific m6A editing systems. M3 methyltransferase-like protein 3 (METTL3), M14 methyltransferase-like protein 14 (METTL14). d Compounds targeting the upstream regulators of ALKBH5. e ALKBH5 gene therapy. ALKBH5 is delivered within a viral vector followed by direct injection to the tumor