Fig. 4
From: Targeting PARP proteins in acute leukemia: DNA damage response inhibition and therapeutic strategies
Schematic representation of PARPi mechanism of action. A SSBs are normally identified and repaired by PARP1 and B the addition of a PARPi compromises the repair and the SSB is converted in DSBs. C PARP1 inhibitors can generate PARP-DNA complexes that during DNA replication can promote DNA replication forks collapse and, consequently, the generation of DSBs. The fate of DSBs depends on HR proficiency of the cancer cells. If the cells are HR proficient, DSBs are repaired and the cells survive, on the contrary, DSBs are not repaired, damages accumulate during replication until cancer cells’ death