From: Targeting PARP proteins in acute leukemia: DNA damage response inhibition and therapeutic strategies
Compound | Primary target(s) | Secondary target(s) | PARP trapping |
---|---|---|---|
Olaparib/AZD-2281/KU005436 | PARP1 | PARP2/3/4 | *** |
Rucaparib/ Rubraca/AG-0146991 | PARP1/2 | PARP2/3/4/10, TNSK1/2 | ** |
Veliparib/ABT-888 | PARP1/2 | * | |
Niraparib/MK-4827 | PARP1/2 | PARP3/4/12 | **** |
Talazoparib/BMN-673 | PARP1/2/3 | PARP4, TNSK1/2 | ***** |