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Table 3 Summary of the available PARP inhibitors with primary and secondary molecular targets and their efficacy in PARP trapping

From: Targeting PARP proteins in acute leukemia: DNA damage response inhibition and therapeutic strategies

Compound

Primary target(s)

Secondary target(s)

PARP trapping

Olaparib/AZD-2281/KU005436

PARP1

PARP2/3/4

***

Rucaparib/ Rubraca/AG-0146991

PARP1/2

PARP2/3/4/10, TNSK1/2

**

Veliparib/ABT-888

PARP1/2

 

*

Niraparib/MK-4827

PARP1/2

PARP3/4/12

****

Talazoparib/BMN-673

PARP1/2/3

PARP4, TNSK1/2

*****

  1. *PARP trapping strength. Stars denotes the intensity trapping, form lower (*) to higher (*****) intensity