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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: Designing strategies of small-molecule compounds for modulating non-coding RNAs in cancer therapy

Fig. 1

ncRNA as potential therapeutic target for cancer. A Abundance of non-coding RNA species: as the pie chart shows, only about 2% of the human genome is used to encode proteins (~ 20,000 proteins). As illustrated at the right, among about 20,000 proteins that make up the human proteome, only 15% are traditionally druggable protein targets. In contrast, ncRNAs, such as lncRNAs, miRNAs and tRNAs, occupy ~ 70% of the genome. Thus, ncRNAs may be a source of potential targets. B Wnt/β-catenin pathway, C PI3K/AKT pathway, D JAK/STAT pathway. Notably, these above-mentioned signaling pathways involved in ncRNAs in the development of cancer are not limited to the above three kinds and the red dotted line represents inhibition, and the green dotted frontal line represents activation

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