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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: Designing strategies of small-molecule compounds for modulating non-coding RNAs in cancer therapy

Fig. 3

Small-molecule compounds for regulating MALAT1 based on SMM. (A) MALAT1 sequence, within which the ENE can be boxed. (B) SMM screening diagram. Small molecules were covalently attached to isocyanate-coated glass slides by chemical methods. The fluorescent labeled MALAT1 triple helix was incubated with the slide. Then the slides were washed to remove the unbound oligonucleotides, and fluorescence scanning imaging was performed at 635 nm. (C) MALAT1 element for nuclear expression (ENE) triplex. (D) The structures of compound 8 and 9

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