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Fig. 4 | Journal of Hematology & Oncology

Fig. 4

From: Designing strategies of small-molecule compounds for modulating non-coding RNAs in cancer therapy

Fig. 4

Prediction and screening of compound 11 as a small-molecule compound regulating ncRNA based on the 3D pre-miR-21 model. (A) Graphical representation of miRNA production. (B) The process of generating sequences of pre-miR-21 hairpin loops (Dicer binding sites on pre-miR-21) from the MIRBASE database. Red bases represented mature miR-21 duplex. (C) 3D structure of pre-miR-21 hairpin loop simulated by using the MC-Fold/MC-Sym calculation method. (D) After screening the molecular docking results, compound 11 not only has high affinity but also has strong biological activity

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