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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: Functions, mechanisms, and therapeutic implications of METTL14 in human cancer

Fig. 2

The METTL3-MEETL14 methyltransferase complex. MTD3 of METTL3 is the real catalyst, while METTL14 stabilizes the structure and promotes RNA substrate recognition to improve methylation transferase activity. The catalytic cavity of METTL3 (DPPW motif) has an open conformation and binds to a cofactor (SAM), and METTL14 (EPPL motif) assumes a closed conformation. The two CCCH (ZnF) moieties of METTL3 are required for RNA substrate binding

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