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Table 2 The function of METTL14 as an m6A methyltransferase in human cancer

From: Functions, mechanisms, and therapeutic implications of METTL14 in human cancer

Role

Cancer type

Upstream

Targets

Reader

Cellular function

Tumor suppressor

Colorectal cancer

Colorectal cancer

MeCP2

miR-375/YAP1

miR-375/SP1

KLF4

IGF2BP2

Growth, migration, and invasion [81]

Proliferation, invasion, and metastasis [82]

 

Colorectal cancer

 

SOX4

YTHDF2

Invasion and metastasis [83]

 

Colorectal cancer

 

XIST

YTHDF2

Proliferation and metastasis [84]

 

Liver cancer

 

EGFR

 

Migration, invasion, and EMT [91]

 

Liver cancer

Liver cancer

 

miR-126

USP48

 

Invasion and metastasis [92]

Tumorigenesis [93]

 

Breast cancer

   

Growth and metastasis [96]

 

Endometrial cancer

 

PHLPP2/

mTORC2

 

Proliferation and tumorigenicity [102]

 

Bladder cancer

 

Notch1

 

Proliferation, self-renewal metastasis, and tumorigenicity [104]

 

Bladder cancer

FOXO3a

Vimentin

 

Migration, invasion, and EMT [105]

 

Glioblastoma

 

ADAM19

 

Growth, self-renewal, and tumorigenesis [111]

 

RCC

RCC

RCC

 

P2RX6

NEAT1_1

BPTF

 

Migration and invasion [115]

Growth and metastasis [116]

Metastasis and EMT [122]

 

PTC

LUAD

 

OIP5-AS1

HCG11

IGF2BP2

Proliferation, migration, and invasion [124]

Growth [129]

 

Gastric cancer

 

Wnt/PI3K-AKT

 

Proliferation and invasion [132]

Oncogene

Skin tumor

 

DDB2

 

Autophagy [159]

 

Pancreatic cancer

 

PERP

 

Proliferation and migration [136]

 

Pancreatic cancer

CLK-1-SRSF5

  

Invasion and metastasis [137]

 

Breast cancer

 

hsa-miR-146a-5p

 

Migration and invasion [138]

 

Breast cancer

Breast cancer

AML

LNC942

AURKA

SPI1

CXCR4/

CYP1B1

DROSHA

MYB/MYC

IGF2BP2

Proliferation and growth [139]

Proliferation [140]

Survival and growth [18]

  1. AML Acute myeloid leukemia, PTC Papillary thyroid carcinoma, LUAD Lung adenocarcinoma, RCC Renal cell carcinoma