Table 2 The function of METTL14 as an m6A methyltransferase in human cancer
From: Functions, mechanisms, and therapeutic implications of METTL14 in human cancer
| Role | Cancer type | Upstream | Targets | Reader | Cellular function |
|---|---|---|---|---|---|
| Tumor suppressor |
Colorectal cancer Colorectal cancer | MeCP2 |
miR-375/YAP1 miR-375/SP1 KLF4 | IGF2BP2 |
Growth, migration, and invasion [81] Proliferation, invasion, and metastasis [82] |
| Colorectal cancer | SOX4 | YTHDF2 | Invasion and metastasis [83] | ||
| Colorectal cancer | XIST | YTHDF2 | Proliferation and metastasis [84] | ||
| Liver cancer | EGFR | Migration, invasion, and EMT [91] | |||
|
Liver cancer Liver cancer |
miR-126 USP48 |
Invasion and metastasis [92] Tumorigenesis [93] | |||
| Breast cancer | Growth and metastasis [96] | ||||
| Endometrial cancer |
PHLPP2/ mTORC2 | Proliferation and tumorigenicity [102] | |||
| Bladder cancer | Notch1 | Proliferation, self-renewal metastasis, and tumorigenicity [104] | |||
| Bladder cancer | FOXO3a | Vimentin | Migration, invasion, and EMT [105] | ||
| Glioblastoma | ADAM19 | Growth, self-renewal, and tumorigenesis [111] | |||
|
RCC RCC RCC |
P2RX6 NEAT1_1 BPTF |
Migration and invasion [115] Growth and metastasis [116] Metastasis and EMT [122] | |||
|
PTC LUAD |
OIP5-AS1 HCG11 | IGF2BP2 |
Proliferation, migration, and invasion [124] Growth [129] | ||
| Gastric cancer | Wnt/PI3K-AKT | Proliferation and invasion [132] | |||
| Oncogene | Skin tumor | DDB2 | Autophagy [159] | ||
| Pancreatic cancer | PERP | Proliferation and migration [136] | |||
| Pancreatic cancer | CLK-1-SRSF5 | Invasion and metastasis [137] | |||
| Breast cancer | hsa-miR-146a-5p | Migration and invasion [138] | |||
|
Breast cancer Breast cancer AML |
LNC942 AURKA SPI1 |
CXCR4/ CYP1B1 DROSHA MYB/MYC | IGF2BP2 |
Proliferation and growth [139] Proliferation [140] Survival and growth [18] |