Skip to main content

Table 2 The function of METTL14 as an m6A methyltransferase in human cancer

From: Functions, mechanisms, and therapeutic implications of METTL14 in human cancer

Role Cancer type Upstream Targets Reader Cellular function
Tumor suppressor Colorectal cancer
Colorectal cancer
MeCP2 miR-375/YAP1
miR-375/SP1
KLF4
IGF2BP2 Growth, migration, and invasion [81]
Proliferation, invasion, and metastasis [82]
  Colorectal cancer   SOX4 YTHDF2 Invasion and metastasis [83]
  Colorectal cancer   XIST YTHDF2 Proliferation and metastasis [84]
  Liver cancer   EGFR   Migration, invasion, and EMT [91]
  Liver cancer
Liver cancer
  miR-126
USP48
  Invasion and metastasis [92]
Tumorigenesis [93]
  Breast cancer     Growth and metastasis [96]
  Endometrial cancer   PHLPP2/
mTORC2
  Proliferation and tumorigenicity [102]
  Bladder cancer   Notch1   Proliferation, self-renewal metastasis, and tumorigenicity [104]
  Bladder cancer FOXO3a Vimentin   Migration, invasion, and EMT [105]
  Glioblastoma   ADAM19   Growth, self-renewal, and tumorigenesis [111]
  RCC
RCC
RCC
  P2RX6
NEAT1_1
BPTF
  Migration and invasion [115]
Growth and metastasis [116]
Metastasis and EMT [122]
  PTC
LUAD
  OIP5-AS1
HCG11
IGF2BP2 Proliferation, migration, and invasion [124]
Growth [129]
  Gastric cancer   Wnt/PI3K-AKT   Proliferation and invasion [132]
Oncogene Skin tumor   DDB2   Autophagy [159]
  Pancreatic cancer   PERP   Proliferation and migration [136]
  Pancreatic cancer CLK-1-SRSF5    Invasion and metastasis [137]
  Breast cancer   hsa-miR-146a-5p   Migration and invasion [138]
  Breast cancer
Breast cancer
AML
LNC942
AURKA
SPI1
CXCR4/
CYP1B1
DROSHA
MYB/MYC
IGF2BP2 Proliferation and growth [139]
Proliferation [140]
Survival and growth [18]
  1. AML Acute myeloid leukemia, PTC Papillary thyroid carcinoma, LUAD Lung adenocarcinoma, RCC Renal cell carcinoma