From: Functions, mechanisms, and therapeutic implications of METTL14 in human cancer
Role | Cancer type | Upstream | Targets | Reader | Cellular function |
---|---|---|---|---|---|
Tumor suppressor | Colorectal cancer Colorectal cancer | MeCP2 | miR-375/YAP1 miR-375/SP1 KLF4 | IGF2BP2 | Growth, migration, and invasion [81] Proliferation, invasion, and metastasis [82] |
 | Colorectal cancer |  | SOX4 | YTHDF2 | Invasion and metastasis [83] |
 | Colorectal cancer |  | XIST | YTHDF2 | Proliferation and metastasis [84] |
 | Liver cancer |  | EGFR |  | Migration, invasion, and EMT [91] |
 | Liver cancer Liver cancer |  | miR-126 USP48 |  | Invasion and metastasis [92] Tumorigenesis [93] |
 | Breast cancer |  |  |  | Growth and metastasis [96] |
 | Endometrial cancer |  | PHLPP2/ mTORC2 |  | Proliferation and tumorigenicity [102] |
 | Bladder cancer |  | Notch1 |  | Proliferation, self-renewal metastasis, and tumorigenicity [104] |
 | Bladder cancer | FOXO3a | Vimentin |  | Migration, invasion, and EMT [105] |
 | Glioblastoma |  | ADAM19 |  | Growth, self-renewal, and tumorigenesis [111] |
 | RCC RCC RCC |  | P2RX6 NEAT1_1 BPTF |  | Migration and invasion [115] Growth and metastasis [116] Metastasis and EMT [122] |
 | PTC LUAD |  | OIP5-AS1 HCG11 | IGF2BP2 | Proliferation, migration, and invasion [124] Growth [129] |
 | Gastric cancer |  | Wnt/PI3K-AKT |  | Proliferation and invasion [132] |
Oncogene | Skin tumor | Â | DDB2 | Â | Autophagy [159] |
 | Pancreatic cancer |  | PERP |  | Proliferation and migration [136] |
 | Pancreatic cancer | CLK-1-SRSF5 |  |  | Invasion and metastasis [137] |
 | Breast cancer |  | hsa-miR-146a-5p |  | Migration and invasion [138] |
 | Breast cancer Breast cancer AML | LNC942 AURKA SPI1 | CXCR4/ CYP1B1 DROSHA MYB/MYC | IGF2BP2 | Proliferation and growth [139] Proliferation [140] Survival and growth [18] |