Fig. 1
From: Deciphering mechanisms of immune escape to inform immunotherapeutic strategies in multiple myeloma
Proteasomal processing and presentation of MHC class I antigens. Proteasomes are essential for immune surveillance and cleave intracellular antigens to provide peptides that are presented on the tumor cell surface to CTLs. Proteasome are key effectors in the cascade of proteolytic processing events required for the generation of antigenic peptides. Resistance to CTLs is mediated by the loss of MHC class I expression or IFN-γ signaling within tumor cells