Fig. 4
From: Deciphering mechanisms of immune escape to inform immunotherapeutic strategies in multiple myeloma
Current and emerging immunotherapeutic strategies in MM. The past two decades has seen an increase in MM patient survival. The first Ab-based FDA-approved immunotherapies, daratumumab and elotuzumab are shown. More recently FDA-approved therapies include efficacious and transformative drugs that harness the immune system. This success has been heralded by idecabtagene vicleucel, the first CAR T cell-based therapy approved for MM. Major areas of development include Ab-drug conjugates, enhancement of T cell and NK-mediated cytotoxicity through CAR T cells, BiTEs and checkpoint blockade [11,12,13,14,15, 178, 179, 181, 185,186,187,188,189,190,191,192,193,194,195]