Table 3 MiRNAs as potential upstream mediators of EZH2 signaling in cancers
From: The long and short non-coding RNAs modulating EZH2 signaling in cancer
MiRNA | Signaling network | Cancer type | In vitro/in vivo | Cell line/Animal model | Remarks | References |
|---|---|---|---|---|---|---|
MiRNA-876-3p | SPRR3/EZH2 | Non-small cell lung cancer | In vitro In vivo | H1299, PC9, HCC827 and A549 cells NOS/SCID mice | Exerting an anti-tumor function Inhibiting SPRR3/EZH2 axis Apoptosis induction Disrupting metastasis | [201] |
MiRNA-21 | – | Lung cancer | In vitro | A549 cell line | MiRNA-21 promotes proliferation and therapy response of cancer cells Silencing miRNA-21 and its downstream target EZH2 enhance therapy sensitivity | [133] |
MiRNA-200c | – | Lung cancer | In vitro | A549 cells | Inhibiting migration and invasion of cancer cells via enhancing E-cadherin levels and decreasing EZH2 expression | [139] |
MiRNA-124 | – | Pancreatic cancer | In vitro | AsPC-1, PANC1, BxPC-3 and SW1990 cells | Impairing metastasis and proliferation of cancer cells Delivery to tumor cells via exosomes EZH2 overexpression disrupts anti-tumor activity of miRNA-124 | [202] |
MiRNA-137 | EZH2/LSD1 | Endometrial cancer | In vitro In vivo | AN3CA, HEC1A, KLE, RL-95-2 cells Xenografts | Suppressing proliferation of cancer cells Inhibiting EZH2 and LSD1 expression levels | [203] |
MiRNA-494 | MYC/EZH2 | Burkitt lymphoma | In vitro | BL cell lines | The MYC can increase EZH2 expression in maintaining malignancy of lymphoma cells MiRNA-494 inhibits MYC/EZH2 axis | [204] |
MiRNA-26a | – | Bladder cancer | In vitro | EJ cells | Apoptosis induction Decreasing proliferation of cancer cells MiRNA-26a inhibits EZH2 signaling | [205] |
MiRNA-98 | EZH2/Wnt/β-catenin | Hepatocellular carcinoma | In vitro | HCCLM3, HepG2, SMMC7721, Hep3 B cell lines | Binding to 3′-UTR of EZH2 and reducing its expression Inactivating Wnt signaling Suppressing cancer growth | [180] |
MiRNA-378a-3p MiRNA-378d | EZH2/STAT3 | Breast cancer | In vitro In vivo | CAL51, MDA-MB-231 and MCF-7 cells Xenografts | Upregulation of EZH2 and subsequent induction of STAT3 signaling in increasing chemoresistance feature and stemness of breast cancer cells | [206] |
MiRNA-124 | EZH2/STAT3 | Cholangiosarcoma | In vitro In vivo | HuCCT1, KMBC, and MZChA1 cells Mouse xenograft model | MiRNA-124 inhibits EZH2 and its downstream target STAT3 Inducing autophagy-related cell death via ATG5 upregulation Reducing miRNA-124 expression enhances disease progression | [207] |
MiRNA-26a | EZH2 | Skin cancer | In vitro | HaCaT cells | Reducing EZH2 expression to mediate UV-induced apoptosis Using EZH2 inhibitors aggravates apoptosis | [208] |