Table 6 The role of CircRNAs in regulating EZH2 expression in different cancers
From: The long and short non-coding RNAs modulating EZH2 signaling in cancer
CircRNA | Signaling network | Cancer type | Signaling network | References |
|---|---|---|---|---|
Hsa-circ-0071589 | MiRNA-600/EZH2 | Colorectal cancer | Reverse association between circRNA and miRNA-600 Reducing miRNA-600 expression via sponging Inducing EZH2 expression and promoting cancer progression | [387] |
Circ-0115744 | MiRNA-144/EZH2 | Colorectal cancer | Reducing miRNA-144 expression and subsequent induction of EZH2 signaling Enhancing cancer metastasis | [392] |
Hsa-circ-0026123 | MiRNA-124-3p/EZH2 | Ovarian cancer | Elevating cancer proliferation and migration Sponging miRNA-124-3p and increasing EZH2 expression | [206] |
Circ-PRMT5 | MiRNA-377/382/498/EZH2 | Non-small cell lung cancer | Decreasing expression levels of miRNAs with tumor-suppressing role Paving the way for EZH2 upregulation Accelerating cancer progression | [390] |
Hsa-circ-0020123 | MiRNA-144/EZH2 | Non-small cell lung cancer | Competitive binding with miRNA-144 and paving the way for EZH2 upregulation in elevating cancer progression | [391] |
Circ-TRPS1 | MiRNA-124-3p/EZH2 | Prostatic cancer | Promoting stemness of cancer cells Reverse relationship between circRNA and miRNA Inducing EZH2 signaling | [393] |
Circ-LRIG3 | EZH2/STAT3 | Hepatocellular carcinoma | Promoting expression level of STAT3 via activating EZH2 to ensure cancer survival | [389] |
Hsa-circ-0000129 | – | Breast cancer | Overexpression of EZH2 as a downstream target of circRNA Enhancing tumor progression Considering as a biomarker | [394] |