From: Circadian rhythms and cancers: the intrinsic links and therapeutic potentials
Cancer types | Disrupted rhythms | Promotion/inhibition | References |
---|---|---|---|
Breast cancer/prostate cancer | Shiftwork-induced disruption of sleep–wake cycles | Promotion | |
Excessive calories-induced disruption of eating–fasting cycles | Promotion | ||
Fasting-induced disruption of eating–fasting cycles | Inhibition | ||
Exercise-induced disruption of activity–rest cycles | Inhibition | ||
Colorectal cancer | Short-term fasting-induced disruption of eating–fasting cycles | Inhibition | |
Maintenance of activity–rest cycles | Inhibition | ||
Per2 mutation-induced disruption of circadian clock | Promotion | [57] | |
Lung cancer | Per2 mutation-induced disruption of circadian clock | Promotion | [23] |
Fasting-induced disruption of eating–fasting cycles | Inhibition | [383] | |
Exercise-induced disruption of activity–rest cycles | Inhibition | [412] | |
Liver cancer | Per1/2 mutation or Bmal1 deletion-induced disruption of circadian clock | Promotion | [60] |
Acute lymphoblastic leukemia | Fasting-induced disruption of eating–fasting cycles | Inhibition | [167] |
T cell lymphomas | Cry1/2 or Rorc deletion-induced disruption of circadian clock | Promotion | |
Glioma | Fasting-induced disruption of eating–fasting cycles | Inhibition | [141] |
Pancreatic cancer | Fasting-induced disruption of eating–fasting cycles | Inhibition | [166] |
Exercise-induced disruption of activity–rest cycles | Inhibition | [426] |