Fig. 9From: Reductive TCA cycle catalyzed by wild-type IDH2 promotes acute myeloid leukemia and is a metabolic vulnerability for potential targeted therapySchematic model depicting the key functions of wild-type IDH2 in AML cells and the impact of IDH2 suppression on α-KG metabolism, fatty acid synthesis, and c-Myc expression (see text for detail description)Back to article page