In situ antigen modification-based target-redirected universal chimeric antigen receptor T (TRUE CAR-T) cell therapy in solid tumors

Table 1 Lipid compositions and physical properties of synthetic nanoparticles used in this study

Nanoparticles^a	Lipid composition (molar ratio, %)			Hydrodynamic size^b (nm)	Surface charge^c (mV)
Nanoparticles^a	DMPC	DSPE-PEG-EvIII	DOTAP	Hydrodynamic size^b (nm)	Surface charge^c (mV)
F-AgNPs	72.5	4	23.5	113.1 ± 1.24	11.2 ± 0.12
P-NPs	96	4	0	112.8 ± 1.18	− 9.2 ± 0.58
NF-NPs	76.5	0	23.5	144.2 ± 0.49	41.3 ± 1.4

^aF-AgNPs, P-NPs, and NF-NPs denote fusogenic antigen loading nanoparticles, PEGylated nonfusogenic nanoparticles, and cationic nonfusogenic nanoparticles respectively
^bMean hydrodynamic sizes of the nanoparticles based on dynamic light scattering measurements (n = 3)
^cMean surface charges of the nanoparticles based on zeta-potential measurements (n = 3)

ISSN: 1756-8722