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Table 1 Lipid compositions and physical properties of synthetic nanoparticles used in this study

From: In situ antigen modification-based target-redirected universal chimeric antigen receptor T (TRUE CAR-T) cell therapy in solid tumors

Nanoparticlesa Lipid composition (molar ratio, %) Hydrodynamic sizeb (nm) Surface chargec (mV)
DMPC DSPE-PEG-EvIII DOTAP
F-AgNPs 72.5 4 23.5 113.1 ± 1.24 11.2 ± 0.12
P-NPs 96 4 0 112.8 ± 1.18 − 9.2 ± 0.58
NF-NPs 76.5 0 23.5 144.2 ± 0.49 41.3 ± 1.4
  1. aF-AgNPs, P-NPs, and NF-NPs denote fusogenic antigen loading nanoparticles, PEGylated nonfusogenic nanoparticles, and cationic nonfusogenic nanoparticles respectively
  2. bMean hydrodynamic sizes of the nanoparticles based on dynamic light scattering measurements (n = 3)
  3. cMean surface charges of the nanoparticles based on zeta-potential measurements (n = 3)