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Table 2 Selected ongoing clinical application of virus-based cancer vaccines (2016–2021)

From: Cancer vaccines as promising immuno-therapeutics: platforms and current progress

NCT number Status Targeted antigens/biological Conditions Phases Category
NCT03136406 Active, not recruiting mutant KRAS Pancreatic Cancer I/II Virus vector
NCT03329248 Active, not recruiting ALT-803, ETBX-011, GI-4000 Pancreatic Cancer I/II Virus vector
NCT03632941 Recruiting HER2 Breast Cancer II Virus vector
NCT04410874 Recruiting MUSIC-01 Non-melanoma Skin Cancer, Squamous /Basal Cell Carcinoma I/II Virus vector
NCT04432597 Recruiting PRGN-2009 HPV-associated Cancers I/II Virus vector
NCT03815942 Active, not recruiting ChAdOx1-MVA 5T4 Prostate Cancer I/II Virus vector
NCT03547999 Active, not recruiting MVA-BN-CV301 Metastatic Colorectal Cancer II Virus vector
NCT03113487 Recruiting p53 Recurrent Ovarian, Primary Peritoneal, Fallopian Tube Cancer II Virus vector
NCT04111172 Recruiting Ad5.F35-hGCC-PADRE Gastrointestinal Adenocarcinoma II Virus vector
NCT03315871 Recruiting PROSTVAC-V/F, CV301 Prostate Cancer II Virus vector
NCT04574583 Active, not recruiting MVA-BN-CV301 Metastatic Cancer, Solid Tumors I/II Virus vector
NCT02649855 Active, not recruiting PROSTVAC-F/V Prostate Cancer, Prostate Neoplasms, Neoplasms, Prostatic II Virus vector
NCT02933255 Recruiting PROSTVAC-V/F Prostate Cancer I/II Virus vector
NCT03563157 Active, not recruiting MUC1, HER2, IL-15 Colorectal Cancer Metastatic, mCRC I/II Virus vector
NCT03953235 Recruiting Neoantigens Non-Small Cell Lung Cancer, Colorectal Cancer, Pancreatic Cancer, Solid Tumor I/II Virus vector/mRNA