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Table 3 Selected ongoing clinical application of peptide-based cancer vaccines (2016–2021)

From: Cancer vaccines as promising immuno-therapeutics: platforms and current progress

NCT number Status Targeted antigens/biological Conditions Phases Category
NCT04747002 Recruiting DSP-7888 Acute Myeloid Leukemia in Remission II Peptide
NCT03946358 Recruiting UCPVax Squamous Cell Carcinoma of the Head and Neck, Anal Canal Cancer, Cervical Cancer II Peptide
NCT04263051 Recruiting UCPVax Advanced Non-small Cell Lung Cancer II Peptide
NCT04382664 Recruiting UV1 Malignant Melanoma II Peptide
NCT04114825 Active, not recruiting RV001V Prostate Cancer Recurrent II Peptide
NCT02938442 Recruiting P10s-PADR Triple Negative Breast Cancer, Breast Neoplasms I/II Peptide
NCT04280848 Recruiting Telomerase Glioblastoma I/II Peptide
NCT02818426 Recruiting UCPVax Metastatic Non-small Cell Lung Cancer I/II Peptide
NCT04369937 Recruiting HPV-16 E6/E7 HPV-Related Squamous Cell Carcinoma, Head and Neck Squamous Cell Carcinoma II Peptide
NCT02654587 Active, not recruiting OSE2101 Non-Small Cell Lung Cancer III Peptide
NCT03149003 Recruiting DSP-7888 Glioblastoma III Peptide
NCT04024800 Active, not recruiting AE37 Peptide Triple-negative Breast Cancer II Peptide
NCT02865135 Active, not recruiting DPX-E7 Cancer of Head and Neck, Cancer of Cervix, Cancer of Anus I/II Peptide
NCT03311334 Recruiting DSP-7888 Renal Cell Carcinoma, Urothelial Carcinoma, Primary Peritoneal Cancer, Ovarian Cancer, I/II Peptide
NCT03012100 Recruiting Folate Receptor-α Breast Cancer II Peptide
NCT03606967 Recruiting Neoantigens Breast Carcinoma II Peptide
NCT04580771 Recruiting HPV-16 E6/E7 Cervical Cancer II Peptide
NCT04206254 Not yet recruiting gp96 Liver Cancer II/III Peptide
NCT03029403 Recruiting DPX-Survivac Advanced Cancer, Ovarian Cancer, Primary Peritoneal Carcinoma, Fallopian Tube Cancer II Peptide
NCT02636582 Active, not recruiting NeuVax Breast Ductal Carcinoma in Situ II Peptide
NCT03715985 Recruiting Neoantigens Malignant Melanoma, Non-Small Cell Lung Cancer Metastatic, Bladder Urothelial Carcinoma, Metastatic I/II Peptide
NCT04197687 Recruiting Multi-epitope HER2 Peptide Breast Cancer II Peptide
NCT03560752 Recruiting CMV-MVA Triplex CMV Viremia in Participants with Blood Cancer Undergoing Donor Stem Cell Transplant II Peptide
NCT04300244 Recruiting UV1 vaccine Malignant Mesothelioma II Peptide
NCT04106115 Not yet recruiting S-488210/S-488211 Bladder Cancer I/II Peptide
NCT03559413 Active, not recruiting Neoantigens Primary, Relapsed Acute Lymphoblastic Leukemia of Childhood, Adolescents and Young Adults I/II Peptide
NCT03258008 Active, not recruiting ISA101b Oropharyngeal Cancer II Peptide
NCT04051307 Recruiting Arginase1, PD-L1 Polycythemia Vera, Essential Thrombocythemia I/II Peptide
NCT04646005 Recruiting ISA101b Cervical Cancer II Peptide
NCT03821272 Recruiting PepCan Head and Neck Cancer I/II Peptide
NCT03761914 Recruiting WT1 Acute Myelogenous Leukemia, Ovarian Cancer, Colorectal Cancer, Triple-negative Breast Cancer, Small-cell Lung Cancer I/II Peptide
NCT04116658 Recruiting EO2401 Glioblastoma I/II Peptide
NCT02960230 Recruiting H3.3K27M Peptide Diffuse Intrinsic Pontine Glioma, Glioma, Diffuse Midline Glioma, H3 K27M-Mutant I/II Peptide
NCT03018288 Active, not recruiting HSPPC-96 Glioblastoma II Peptide
NCT02795988 Active, not recruiting IMU-131 Gastrointestinal Neoplasms, Adenocarcinoma I/II Peptide
NCT02785250 Active, not recruiting DPX-Survivac Recurrent Epithelial Ovarian Cancer, Recurrent Fallopian Tube Cancer, Recurrent Peritoneal Cancer I/II Peptide
NCT04060277 Recruiting Triplex Leukemia, Lymphoma II Peptide
NCT03848039 Not yet recruiting Gardasil-9 Cervical Intraepithelial Neoplasia III Protein
NCT03979014 Not yet recruiting GARDASIL9 Neoplasia III Protein
NCT02955290 Active, not recruiting CIMAvax Non-small Cell Lung Cancer, Squamous Head and Neck Cancer I/II Protein
NCT04910802 Recruiting Gardasil9 HPV Infection, CIN 2, 3, Cervical Cancer IV Protein
NCT03284866 Recruiting Gardasil 9 AIDS-Related Human Papillomavirus Infection, High Grade Cervical Squamous Intraepithelial Neoplasia, HIV Infection III Protein
NCT03206047 Active, not recruiting CDX-1401 Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal I/II Protein
NCT03728881 Active, not recruiting Cervarix, Gardasil Human Papillomavirus-Related Cervical Carcinoma III Protein
NCT02568566 Active, not recruiting Gardasil 9 Human Papillomavirus-Related Carcinoma II Protein
NCT03180034 Active, not recruiting Gardasil, DTaP, Cervarix Human Papillomavirus-Related Cervical Carcinoma IV Protein
NCT04635423 Recruiting V503 Warts, Genital, Neoplasms, Anal III Protein
NCT04782895 Active, not recruiting Gardasil®9 Cervical Cancer, Condylomata Acuminata III Protein
NCT02834637 Active, not recruiting Cervarix, Gardasil 9 Human Papilloma Virus III Protein
NCT04508309 Recruiting Gardasil®, Cecolin® Cervical Cancer III Protein
NCT03675256 Active, not recruiting Gardasil 9, Cervarix Papillomavirus Infections IV Protein
NCT03036930 Active, not recruiting Gardasil 9 Human Papillomavirus Infection II Protein
NCT04274153 Recruiting Gardasil9 Immunization, Human Papilloma Virus IV Protein
NCT03702231 Active, not recruiting Zoster Vaccine Recombinant Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma II Protein
NCT04459221 Recruiting Gardasil 9 Papilloma Viral Infection IV Protein
NCT03579654 Not yet recruiting PSA, IL-2, GM-CSF Prostate Cancer II Protein