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Table 4 Selected ongoing clinical application of nucleic acid-based cancer vaccines (2016–2021)

From: Cancer vaccines as promising immuno-therapeutics: platforms and current progress

NCT number Status Targeted antigens/biological Conditions Phases Category
NCT04090528 Recruiting pTVG-HP, pTVG-AR Prostate Cancer, Metastatic Cancer II DNA
NCT03439085 Recruiting VGX-3100 Human Papillomavirus Associated Cancers II DNA
NCT03600350 Recruiting pTGV-HP Prostate Cancer II DNA
NCT03603808 Recruiting VGX-3100 HIV-Positive High-Grade Anal Lesions II DNA
NCT03444376 Recruiting GX188E Cervical Cancer I/II DNA
NCT04405349 Recruiting VB10.16 Cervical Cancer, Cervix Cancer II DNA
NCT03548467 Active, not recruiting VB10.NEO Locally Advanced or Metastatic Solid tumors I/II DNA
NCT02780401 Active, not recruiting HER2, IGFBP2, IFG-1R Breast Cancer I DNA
NCT03199040 Active, not recruiting Neoantigens Breast Cancer I DNA
NCT03532217 Active, not recruiting Neoantigens Metastatic Hormone-Sensitive Prostate Cancer I DNA
NCT03721978 Recruiting VGX-3100 Cervical Dysplasia, Cervical High Grade Squamous Intraepithelial Lesion III DNA
NCT03502785 Active, not recruiting INO-9012 Urothelial Carcinoma I/II DNA
NCT03655756 Active, not recruiting Emm55 streptococcal antigen Cutaneous Melanoma Early Phase I DNA
NCT03491683 Active, not recruiting WT1, PSMA, hTERT Glioblastoma I/II DNA
NCT03122106 Active, not recruiting Neoantigens Pancreatic Cancer, Cancer of the Pancreas I DNA
NCT03897881 Recruiting Neoantigens Melanoma II mRNA
NCT03639714 Active, not recruiting Neoantigens Non-Small Cell Lung Cancer, Colorectal Cancer, Gastroesophageal I/II mRNA
NCT04382898 Recruiting W-pro1 (BNT112) Prostate Cancer I/II mRNA
NCT04534205 Recruiting BNT113 Head and Neck Cancer II mRNA
NCT04526899 Recruiting NY-ESO-1, MAGE-A3, Tyrosinase, TPTE Melanoma Stage III/IV II mRNA
NCT03164772 Active, not recruiting NY-ESO-1, MAGEC1, MAGE-C2, 5 T4, Surviving, MUC1 Metastatic Non-small Cell Lung Cancer, NSCLC I/II mRNA
NCT04163094 Recruiting W-ova1 Ovarian Cancer I mRNA
NCT03468244 Recruiting Neoantigens Digestive System Cancer Not Applicable mRNA
NCT03313778 Recruiting Neoantigens Solid Tumors I mRNA
NCT03948763 Recruiting KRAS mutations Neoplasms, NSCLC, Pancreatic Neoplasms, Colorectal Neoplasms I mRNA
NCT03289962 Recruiting Neoantigens Melanoma, Non-Small Cell Lung I mRNA
NCT03815058 Recruiting Neoantigens Advanced Melanoma II mRNA
NCT04486378 Recruiting Neoantigens Colorectal Cancer II mRNA
NCT04161755 Recruiting Neoantigens Pancreatic Cancer I mRNA
NCT03788083 Recruiting Trimix mRNA (mRNA encoding CD40L, CD70, acTLR4) Breast Cancer Female, Early-stage Breast Cancer I mRNA
NCT03323398 Active, not recruiting mRNA-2416 (mRNA encoding OX40L) Relapsed/Refractory Solid Tumor Malignancies or Lymphoma, Ovarian Cancer I/II mRNA
NCT03739931 Recruiting mRNA-2752 (mRNA encoding OX40L, IL-23, IL-36Ƴ) Relapsed/Refractory Solid Tumor Malignancies or Lymphoma, Other Solid Tumor I mRNA
NCT03289962 Active, not recruiting Neoantigens Locally Advanced or Metastatic Tumors I mRNA