Fig. 4From: Targeting the histone H3 lysine 79 methyltransferase DOT1L in MLL-rearranged leukemiasSchematic representation of protesolysis-targeting chimera (PROTAC) degraders. A protein of interest (POI) can be degraded by the ubiquitin–proteasome system, which is mediated by a PROTAC and consists of a POI ligand connected to an E3 ligand via a linker. The PROTAC molecule is recycled to induce the next round of degradationBack to article page