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Fig. 6 | Journal of Hematology & Oncology

Fig. 6

From: Targeting the histone H3 lysine 79 methyltransferase DOT1L in MLL-rearranged leukemias

Fig. 6

Close-up view of DOT1L in complex with other epigenetic regulators. a Solution NMR structure of DOT1L in complex with AF9 (DOT1L-AF9) (PDB: 2MV7). b Solution structure of the AF4–AF9 complex (PDB: 2LM0). c Crystal structure of the coiled-coil domains of human DOT1L in complex with AF10 (PDB: 6JN2). d Structure of the DOT1L-H2BK120ub nucleosome complex (PDB: 6NN6). e Crystal structure of the RNF20 RING domain (PDB: 5TRB). f Active DOT1L bound to the H4K16ac nucleosome (PDB: 7K6Q)

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