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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy

Fig. 1

The regulation of ECM stiffness by tumor and stromal cells. Hypoxia or growth factors such as TGFβ can induce the expression of collagen/elastin cross-linking factors in tumor and stromal cells, leading to increased ECM stiffness. ECM stiffening reciprocally acts on tumor and stromal cells thereby generating a vicious cycling. M, macrophage; CAF, cancer-associated fibroblast; MSC, mesenchymal stem cell

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