Fig. 6

Comparison of various effector T cell subtypes between cholangiocarcinomas with higher versus lower density of regulatory immune cells. Tumors are subgrouped by higher density versus lower density of two immune cell subgroups of CD4⁺PD-1⁺ T cells in A, D, G, J, Tregs in B, E, H, K, CSF1-R⁺ myeloid cells in C, I, F, L. The density of CD8⁺ T-cells (A-C), CD8⁺Ki67⁺ T-cells (D-F), CD8⁺Granzyme B⁺ T-cells (G–I), CD8⁺PD-1⁺ T-cells (J–L) was compared between the two subgroups. t tests were performed with p value indicated. DCC, distal cholangiocarcinoma; HC, hilar cholangiocarcinoma; ICC, intrahepatic cholangiocarcinoma