Immune cell atlas of cholangiocarcinomas reveals distinct tumor microenvironments and associated prognoses

Xia, Tao; Li, Keyu; Niu, Nan; Shao, Yingkuan; Ding, Ding; Thomas, Dwayne L.; Jing, Hao; Fujiwara, Kenji; Hu, Haijie; Osipov, Arsen; Yuan, Chunhui; Wolfgang, Christopher L.; Thompson, Elizabeth D.; Anders, Robert A.; He, Jin; Mou, Yiping; Murphy, Adrian G.; Zheng, Lei

doi:10.1186/s13045-022-01253-z

Journal of Hematology & Oncology

Table 1 Summary of univariate and multivariate logistic analysis of the association between the density of effector T cells or tumor associated macrophages (TAM) and OS < 3 years

From: Immune cell atlas of cholangiocarcinomas reveals distinct tumor microenvironments and associated prognoses

BTC type	Immune cell subtypes	Univariate Analysis			Multivariate analysis
BTC type	Immune cell subtypes	Odds ratio	95% CI	p value	Odds ratio	95% CI	p value
DCC	CD8⁺ T cells: High versus Low	0.276	0.062, 1.233	0.092	0.238	0.049, 1.158	0.075
HC	CD8⁺ T cells: High versus Low	0.167	0.532, 67.64	0.147	0.181	0.015, 2.24	0.183
ICC	CD8⁺ T cells: High versus Low	0.222	0.058, 0.858	0.029	0.218	0.038, 1.247	0.087
DCC	CD8⁺ Granzyme B⁺ T cells: High versus Low	0.144	0.027, 0.778	0.024	0.114	0.122, 2.062	0.02
HC	CD8⁺ Granzyme B⁺ T cells: High versus Low	0.583	0.075, 4.562	0.608	0.287	0.017, 4.835	0.386
ICC	CD8⁺ Granzyme B⁺ T cells: High versus low	0.222	0.058, 0.858	0.029	0.269	0.05, 1.435	0.124
DCC	CD8⁺EOMES⁻PD-1⁻ T cells: High versus Low	0.476	0.117, 1.944	0.301	0.501	0.122, 2.062	0.338
HC	CD8⁺ EOMES⁻PD-1⁻ T cells: High versus Low	0	0, Infinity*	0.995	0	0, Infinity*	0.996
ICC	CD8⁺EOMES⁻PD-1⁻ T cells: High versus low	0.076	0.016,0.358	0.001	0.049	0.006, 0.433	0.007
DCC	PD-L1⁺ CSF-1R⁺ TAM: High versus Low	6.923	1.285, 37.287	0.024	8.173	1.402, 47.635	0.019
HC	PD-L1⁺ CSF-1R⁺ TAM: High versus Low	1.714	0.219, 13.406	0.608	5.583	0.261, 119.634	0.271
ICC	PD-L1⁺ CSF-1R⁺ TAM: High versus Low	7.429	1.778, 31.04	0.006	10.152	1.658,62.177	0.012
DCC	M1 TAM: High versus Low	0.476	0.117, 1.944	0.301	0.449	0.105, 1.927	0.281
HC	M1 TAM: High versus Low	0.583	0.075, 4.562	0.608	0.527	0.062, 4.449	0.556
ICC	M1 TAM: High versus Low	0.222	0.058, 0.858	0.029	0.208	0.039, 1.104	0.065
DCC	PD-L1⁺ M1 TAM: High versus Low	6.923	1.285, 37.287	0.024	7.07	1.303, 38.349	0.023
HC	PD-L1⁺ M1 TAM: High versus Low	1.714	0.219, 13.406	0.608	0.665	0.041, 10.784	0.774
ICC	PD-L1⁺ M1 TAM: High versus Low	2.852	0.777,10.467	0.114	6.166	0.875,43.46	0.068
DCC	M2 TAM: High versus Low	6.923	1.285, 37.287	0.024	7.473	1.365, 40.907	0.02
HC	M2 TAM: High versus Low	6	0.532, 67.64	0.147	5.194	0.213, 126.625	0.312
ICC	M2 TAM: High versus Low	1.227	0.35,4.307	0.749	2.35	0.467,11.831	0.3
DCC	PD-L1⁺ M2 TAM: High versus Low	3 × 10⁸	0, Infinity*	0.993	3 × 10⁸	0, Infinity*	0.993
HC	PD-L1⁺ M2 TAM: High versus Low	0.583	0.075, 4.562	0.608	0.244	0.012, 5.12	0.364
ICC	PD-L1⁺ M2 TAM: High versus Low	7.429	1.778, 31.04	0.006	10.812	1.63, 71.735	0.014

*Tumors from all the patients with OS > 3 years or from all the patients with OS < 3 years have a “higher” immune cell density; BTC, biliary tract cancer; DCC, distal cholangiocarcinoma; HC, hilar cholangiocarcinoma; ICC, intrahepatic cholangiocarcinoma

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