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Table 1 New risk scoring system created from the extracted VTE risk factors

From: A new risk-assessment tool for venous thromboembolism in advanced lung cancer: a prospective, observational study

Parameter

Coefficient

OR

95% CI

p-value

Score point

Overview of the risk score

     

 Sex, Female (vs. Male)

0.730

2.076

1.257–3.429

0.004

1

 Adenocarcinoma (vs. non-small cell lung cancer, others)

0.845

2.327

1.277–4.241

0.006

1

 N type, 3 (vs. 0–2)

0.754

2.125

1.299–3.475

0.003

1

 Eastern Co-operative Oncology group performance status, 1–3 (vs. 0)

0.754

2.125

1.220–3.704

0.008

1

 Lymphocyte percentage < 18%

0.763

2.145

1.293–3.557

0.003

1

 Platelet count < 280,000/μL

0.747

2.110

1.238–3.595

0.006

1

 Prothrombin fragment 1 + 2 ≥ 325 pmol/L

0.768

2.155

1.313–3.535

0.002

1

 Diastolic blood pressure ≥ 70 mmHg

0.658

1.931

1.122–3.325

0.018

1

Points calculated from score

VTE incidence rate

Estimation of the VTE incidence rate using the new risk-assessment scoring system

 0

0.003

 1

0.007

 2

0.015

 3

0.031

 4

0.064

 5

0.127

 6

0.237

 7

0.398

 8

0.584

  1. Cut-off values for lymphocyte percentage, platelet count, prothrombin fragment 1 + 2 level, and diastolic blood pressure were estimated by ROC analysis
  2. As VTE was observed in 100 of the 1008 cases (incidence rate: 0.099) in the Rising-VTE/NEJ037 Study, scores ≥ 5 were classified into the high-risk group
  3. VTE, venous thromboembolism; CI, confidence interval; OR, odds ratio