Fig. 2
From: Emerging role of RNA sensors in tumor microenvironment and immunotherapy
Model for RNA Sensing in the context of anti-tumor immunity. RNA sensors can induce anti-tumor efficacy through multiple mechanisms. Tumor-derived Type I IFN and antigen which contain RNA activates antigen-presenting cells (APC), which mainly including DCs and macrophages. RNA sensors in APCs sense RNA and promote DCs mature and macrophage M1 polarization. Then these cells trigger production of type I IFN and other proinflammatory factors to promote an antitumor immune microenvironment by activating T cells, NK cells and inhibiting Treg and MDSC cells