Fig. 3

Contribution of RNA sensors in cancer immunotherapy. RNA sensor agonists singly use benefit to cancer immunotherapy by boosting anti-cancer immune response. When loaded into some vehicles such as liposomes, nanoparticle and some novel compounds, they get more effective drug concentration in tumor bed. RNA sensor agonists can also act as adjuvant for other cancer immunotherapy strategies including cancer vaccines, immune cells engineering, immune checkpoint therapy and chemoradiotherapy to induce antitumor immune microenvironment, ameliorate the treatment efficacy and reduce the side effects