Emerging role of RNA sensors in tumor microenvironment and immunotherapy

Yang, Rui; Yu, Sihui; Xu, Tianhan; Zhang, Jiawen; Wu, Sufang

doi:10.1186/s13045-022-01261-z

Journal of Hematology & Oncology

Table 2 The roles of RNA sensors in cancer immunity

From: Emerging role of RNA sensors in tumor microenvironment and immunotherapy

RNA sensors	Cancers	Effect on immune microenvironment	Outcome	References
TLR3	NSCLC	DC, NK, CTL activation, macrophage M1 polarization	Suppression	[23, 30, 34]
	Breast cancer	DC, CTL activation IL-12, IFN-γ production	Suppression	[28]
	Lung cancer	IL-1β release	Progression	[36]
	Melanoma	DC, NK cells activation PD-L1 decrease	Suppression	[29, 32, 33, 35]
	Colon cancer	Macrophage M1 polarization	Suppression	[31]
	Breast and lung cancer	Chemotactic signalling pathway	Progression	[40]
TLR7	Melanoma	TAM decrease	Suppression	[35]
	NSCLC	MDSCs recruitment	Progression, metastasis	[38]
	STAD	T cells, macrophages, NK and DC infiltration	Suppression	[42]
TLR8	Prostate cancer	CD8⁺ Treg cells suppression	Suppression	[46]
	Breast cancer	Gammadelta T cells, Treg, MDSCs suppression	Suppression	[48, 49, 55]
	Melanoma	Treg cells suppression	Suppression	[50]
	Solid tumor cells	Tumor-induced T cell and DC senescence prevention, MDSCs apoptosis	Suppression	[51, 52]
	Head and neck cancer	MDSCs suppression, M1 monocyte and CD8⁺ T cells infiltration	Suppression	[54]
RIG-I	Melanoma	CD8⁺ T cells, NK cells response	Suppression	[60, 62]
	Lung cancer	Reduction of exhausted CD8⁺ T cells	Suppression	[70]
	Hepatocellular carcinoma	Macrophages M1 polarization	Suppression	[61]
	Ovarian cancer	IFN production, PD-L1 over-expression	Progression	[63]
	Nasopharyngeal carcinoma	PD-L1 over-expression	Progression	[64]
MDA5	Melanoma	IFN and IL15 production, CTL expansion	Suppression	[65]
	Solid tumor cells	Th1 T cells differentiation, IFN response	Suppression	[66]
LGP2	Breast cancer	DC activation, IFN-1 production, CD8⁺ T cells infiltration	Suppression	[67]
NOD2	Lung adenocarcinoma	Macrophages M2 polarization	Progression	[71]

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