From: Emerging role of RNA sensors in tumor microenvironment and immunotherapy
Agonists name | Chemical properties | Target | Cancer | Function | References |
---|---|---|---|---|---|
ARNAX | dsRNA | TLR3 | Lymphoma | Involves in the recruitment and function of T cells, NK cells and DCs, overcame anti-PD-1 resistance | |
RNA-OG | ssRNA | TLR3 | Mice peritoneal metastatic colon cancer model | Activates CD8+ T and NK cells, antagonizes the peritoneal immunosuppressive TME, produces type-I IFN | [104] |
ssRNA-Pim-3-shRNA | ssRNA | TLR7 | Melanoma | Activates CD8+ T cells and HK cells and reducts intratumoral Treg and MDSCs | [105] |
CircNDUFB2 | Noncoding RNA | RIG-I | NSCLC | Activates RIG-I-MAVS signaling cascades and recruits immune cells into the TME | [107] |
CircBART2.2 | Noncoding RNA | RIG-I | Nasopharyngeal carcinoma | Induces PD-L1 transcription, activates NF-κB and IRF3 cascades | [74] |
ppp-RNA | RNA | RIG-I | Melanoma and acute myeloid leukemia | Activates CD4+ and CD8+ T cells, induced PD-L1 expression | |
PVSRIPO | Recombinant poliovirus | MDA5 | Glioma | Induces IFN response and elicits antitumor T cell immunity | |
17e (CU-CPT17e) | Small molecule | TLR3, 8 and 9 | HeLa cancer cells | Produces various cytokines | [109] |
1V270 | Small molecule | TLR7 | HNSCC and melanoma mice models | Induces tumor-specific adaptive immune responses | |
MEDI9197 (3M-052) | Small molecule | TLR7/8 | Melanoma | Regulates the enrichment and activation of CD8+ T cells and NK cells, polarization of Th1 cells | [113] |