Fig. 2

Parameters associated with extramedullary manifestations in AML. Logistic regression was used to obtain univariable odds ratios for presence or absence of extramedullary manifestations (EM) in AML patients (A). We found the presence of EM to be significantly associated with cytomorphologic phenotypes according to the French-American-British (FAB) classification. FAB-M5a and -M5b were associated with increased odds while -M2 and -M6 were associated with decreased odds. As for molecular genetics, mutations of NPM1, FLT3-ITD and PTPN11 were associated with EM while IDH2 and CEBPA were less likely to be associated with EM. Previous reports have suggested an association of inv [16], t(8;21) and trisomy 8 with EM, however in our analysis we did not find a statistically significant association. Molecular and cytogenetic interconnections of patients with (B) or without (C) EM AML are displayed