Fig. 4

Risk factors in acute myeloid leukemia with extramedullary manifestations. Among AML patients bearing extramedullary manifestations (EM) mutations of TP53 and IKZF1 were rare (7/225 [3.1%] and 9/225 [4.0%], respectively). However, EM AML patients with TP53 mutations showed significantly decreased event-free (A) and overall survival (B). Likewise, EM AML patients with IKZF1 mutations also showed significantly decreased event-free (C) and overall survival (D)