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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: A novel tRNA-derived fragment AS-tDR-007333 promotes the malignancy of NSCLC via the HSPB1/MED29 and ELK4/MED29 axes

Fig. 3

AS-tDR-007333 promotes proliferation and migration capacity of NSCLC cells. A, C Overexpression of AS-tDR-007333 promoted proliferation rates of A549 and PC9 cells. B, D Knockdown of AS-tDR-007333 with inhibitor suppressed cell proliferation in A549 and PC9 cells. E, G Cell cycle analysis revealed that the percentages of S phase cells in AS-tDR-007333-overexpressed PC9 cells were increased as compared with their negative controls. F, H Knockdown of AS-tDR-007333 reduced the rate of S phase cells in PC9 cell line. I, K Up-regulation of AS-tDR-007333 increased the number of S phase cells in A549 cells. J, L Knockdown of AS-tDR-007333 reduced the rate of S phase cells in A549 cells. M–Q Transwell assays showed that up-regulation of AS-tDR-007333 increased the numbers of migrated cells, but knockdown of AS-tDR-007333 reduced the numbers of migrated cells. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001

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