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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: 3D chromatin architecture and transcription regulation in cancer

Fig. 3

The relevance of 3D chromatin interactions in biological processes. Chromatin looping regulates gene expression in diverse cellular processes. Protein complexes for the chromatin loop bring enhancers in physical contact with promoters and thereby regulate gene expression. The dynamical changes in 3D chromatin architecture are likely to be important for regulating many biological processes during tumorigenesis, including cancer stem cell formation and metastatic processes, the dynamical changes of chromatin during the cell cycle, and the clonal evolution during tumorigenesis that results in different cancer cell characteristics

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