Fig. 3

LncRNA-PACERR⁺ TAMs facilitate PDAC cell growth and liver metastasis in vivo. A Images of BALB/c nude mice which were co-injected with THP-1 cells and PATU-8988 cells subcutaneously. B Images of subcutaneous tumours. C, D Tumour weights and volumes of the subcutaneous xenografts. E, G Kaplan–Meier survival curve presenting the overall survival of BALB/c nude mice (shNC/sh1 PACERR groups) (n = 6). F Representative images of liver metastasis and the number of metastatic cells in PDAC mouse model, in which PATU-8988 cells mixed with TAMs (THP-1 shNC/sh1 LncRNA-PACERR) were injected into the spleens of BALB/c nude mice. Data iare shown as the results from three independent experiments. H Representative images of IHC (CD163 and CD206) of liver metastasis and the number of CD163⁺ and CD206⁺ cells in metastatic foci from liver tissues. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001