From: Single-cell sequencing: a promising approach for uncovering the mechanisms of tumor metastasis
Disease type | Sample type | Number | Detection Method | Conclusion | Ref |
---|---|---|---|---|---|
Diabetic kidney | Cells | – | scRNA-seq | Revealed the dynamic changes of gene expression in the diabetic kidney | [36] |
Rheumatoid arthritis | Cells | 51 patients | scRNA-seq | Discovered the key mediators of the pathogenesis of RA | [37] |
Heart injury | Cells | 30,000 cells | scRNA-seq | Provided an in-depth analysis of the entry points of cardiac homeostasis, inflammation, fibrosis, repair and regeneration | [38] |
Alzheimer's disease | Cells | 38,731 cells | scRNA-seq | Discovered potential signaling pathways in Alzheimer's disease | [39] |
Biliary atresia | Cells | – | scRNA-seq | Demonstrated that B cell modification therapy can alleviate liver pathology | [40] |
Cirrhosis | Cells | 4076 cells | 10 × scRNA-seq | Displayed the development of novel therapeutic strategies to target the most dysfunctional liver ECs | [41] |
Placenta | Cells | — | scRNA-seq | Revealed the unprecedented depth for the investigation of cell type-specific gene expression patterns in the placenta | [42] |
SARS-CoV-2 | Cells | 7 patients | scRNA-seq | Provided potential therapeutic targets for cell resistance | [43] |
Lung adenocarcinoma | Cells | 208,506 cells | scRNA-seq | Identified a cancer cell subtype deviating from the normal differentiation trajectory | [44] |
Pan-cancer | Cells | 21 types of cancer cells | scRNA-seq | Revealed distinct patterns of T cell composition | [45] |