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Table 2 Application of SCS in human diseases

From: Single-cell sequencing: a promising approach for uncovering the mechanisms of tumor metastasis

Disease type

Sample type

Number

Detection

Method

Conclusion

Ref

Diabetic kidney

Cells

–

scRNA-seq

Revealed the dynamic changes of gene expression in the diabetic kidney

[36]

Rheumatoid

arthritis

Cells

51 patients

scRNA-seq

Discovered the key mediators of the pathogenesis of RA

[37]

Heart injury

Cells

30,000 cells

scRNA-seq

Provided an in-depth analysis of the entry points of cardiac homeostasis, inflammation, fibrosis, repair and regeneration

[38]

Alzheimer's

disease

Cells

38,731 cells

scRNA-seq

Discovered potential signaling pathways in Alzheimer's disease

[39]

Biliary atresia

Cells

–

scRNA-seq

Demonstrated that B cell modification therapy can alleviate liver pathology

[40]

Cirrhosis

Cells

4076 cells

10 × scRNA-seq

Displayed the development of novel therapeutic strategies to target the most dysfunctional liver ECs

[41]

Placenta

Cells

—

scRNA-seq

Revealed the unprecedented depth for the investigation of cell type-specific gene expression patterns in the placenta

[42]

SARS-CoV-2

Cells

7 patients

scRNA-seq

Provided potential therapeutic targets for cell resistance

[43]

Lung adenocarcinoma

Cells

208,506 cells

scRNA-seq

Identified a cancer cell subtype deviating from the normal differentiation trajectory

[44]

Pan-cancer

Cells

21 types of cancer cells

scRNA-seq

Revealed distinct patterns of T cell composition

[45]