Fig. 2
From: Immunosuppressive cells in cancer: mechanisms and potential therapeutic targets
The potential strategies to target MDSCs. MDSC is the main type of immunosuppressive cell in cancer. Strategies targeting MDSCs to reverse the immunosuppression include depleting the populations of MDSCs by targeting VEGFR and CD33, blocking the migration and recruitment of MDSCs into TME by targeting the CCR2 or CXCR1/2, inhibiting the activity of MDSCs by targeting PGE2 and IDO, promoting the differentiation of MDSCs by TLR agonists, and inhibiting the metabolism of MDSCs by targeting FATP2 and CPT1