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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: Immunosuppressive cells in cancer: mechanisms and potential therapeutic targets

Fig. 3

The potential targets of TAMs in cancer therapy. M2-type TAMs in TME mediate the immunosuppression and promote the growth of tumor cells, as well as the resistance of cancer to immunotherapy. Strategies targeting the TAMs to reverse the immunosuppression include depleting and blocking the recruitment of TAMs into TME by targeting the CCR2 or CXCR1/2, targeting the activation of TAMs by CD40 and TLR7/8, modulating the phagocytosis of TAMs by targeting SIRPα, LILRB1, and Siglec-10. Furthermore, with the development of adoptive cell therapy, CAR-M represents a novel strategy that applies modified macrophages by adding specific CAR to them, which enhances the phagocytosis of macrophages on tumor cells. Besides, other advantages of CAR-M are identified, such as the resistance of CAR-M being polarized to M2 type

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