Fig. 4

The currently proposed therapy based on TANs targeting. Neutrophil is the first responder to injury. However, the roles and importance of neutrophils in inducing the tumor progression as well as the generation of immunosuppressive microenvironment have been revealed recently. Strategies targeting the TANs to reverse the immunosuppression include depleting and blocking the recruitment of TANs into TME by targeting the CXCR1/2, CXCR4, and CSF-1R, inhibiting the functions of TANs by targeting VEGFR and PGE2, blocking the development of TANs by IL-17/IL-23 inhibitors, and reprogramming TANs by targeting TGF-β, NAMPT, and FATP2