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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: The potential role of N7-methylguanosine (m7G) in cancer

Fig. 1

The cellular m7G modification machinery. The m7G modification is a multilayered process. The m7G methyltransferases have been identified as METTL1, WDR4, RNMT, RAM, WBSCR22, and TMRT112, which install the m7G modification on target RNA molecules, including mRNA, tRNA, rRNA, and miRNA. The METTL1/WDR4 complex installs m7G modification on mRNA (internal site), tRNA (G46 site), and miRNA (G-quadruplex structure), ultimately regulating global translation. The RNMT/RAM complex is responsible for installation of the m7G modification on the 5’ cap of mRNA, mediating its nuclear export and translation processes. The WBSCR22/TMRT112 complex adds m7G modification at the G1638 site of 18 s rRNA, which facilitates 18 s rRNA maturation

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