Table 1 The roles of m7G regulators and underlying molecular mechanisms in cancer
From: The potential role of N7-methylguanosine (m7G) in cancer
Cancer types | m7G regulators | Expression | Molecular axis | Function | Role in cancer | References |
|---|---|---|---|---|---|---|
AML | METTL1 WDR4 | Upregulation Upregulation | METTL1/WDR4/Arg-TCT-4-1/cell cycle genes | Promoting cell growth, proliferation, and tumor formation | Oncogene Oncogene | [43] |
BC | METTL1 | Upregulation | METTL1/EGFR/EFEMP1 | Promoting cell proliferation, migration, and invasion | Oncogene | [26] |
CC | METTL1 | Downregulation | METTL1/let-7e miRNA/HMGA2 | Inhibiting cell proliferation, migration, and invasion. | Anti-oncogene | [48] |
| Â | WBSCR22 | Upregulation | METTL1/miR-149-3P/P53/S100A4 | Promoting cell sensitivity to cisplatin | Oncogene | [49] |
| Â | Â | Â | Â | Promoting cell apoptosis and resistance to oxaliplatin | Â | [50] |
ESCC | METTL1 WDR4 | Upregulation Upregulation | METTL1/WDR4/RPTOR/ULK1/autophagy pathway | Promoting cell proliferation and tumor formation | Oncogene Oncogene | [52] |
Glioma | METTL1 | Upregulation | METTL1/MAPK pathway | Promoting cell growth and proliferation | Oncogene | [56] |
|  | WBSCR22 | Upregulation | PI3K/AKT/GSK3β pathway | Promoting cell growth and metastasis | Oncogene | [57] |
HCC | METTL1 | Upregulation | METTL1/WDR4/PTEN pathway | Promoting cell proliferation and migration | Oncogene | [60] |
METTL1/WDR4/Cyclin A2/EGFR/VEGFA | Promoting cell growth, invasion, and migration | Oncogene | [24] | |||
| Â | WDR4 | Upregulation | WDR4/EIF2A/CCNB1 | Promoting cell growth, migration, and resistance to sorafenib | Oncogene | [61] |
HNSCC | METTL1 | Upregulation | METLL1/WDR4/ PI3K/AKT/mTOR pathway | Promoting cell growth, migration, and invasion | Oncogene | [59] |
WDR4 | Upregulation | Oncogene | ||||
ICC | METTL1 | Upregulation | METTL1/WDR4/cell cycle and EGFR-related genes | Promoting cell growth, proliferation, migration, and invasion | Oncogene | [66] |
WDR4 | Upregulation | Oncogene | Â | |||
LC | METTL1 | Upregulation | METTL1/WDR4/CCND3/CCNE1 | Promoting cell proliferation, migration, and invasion | Anti-oncogene/oncogene | [68] |
METTL1/AKT/mTORC1 pathway | Promoting cell proliferation and autophagy | Â | [69] | |||
METTL1/let-7 miRNA | Inhibiting cell migration | Â | [13] | |||
WDR4 | Upregulation | WDR4/PML/uPAR/SAA2/MMP2/MMP9 | Promoting cell metastasis | Oncogene | [70] | |
NPC | METTL1 | Upregulation | METTL1/WDR4/WNT/EMT pathway | Promoting cell proliferation, migration, and invasion | Oncogene | [78] |
WDR4 | Upregulation | Oncogene | ||||
PC | WBSCR22 | Downregulation | WBSCR22/TRMT112/ISG15 | Inhibiting cell proliferation, invasion, and tumor formation | Anti-oncogene | [80] |