From: Emerging role of exosomes in cancer progression and tumor microenvironment remodeling
Exosomal ncRNA | Signaling network | Cancer type | Remarks | Refs |
---|---|---|---|---|
miRNA-34a | – | Breast cancer | Proliferation of cancer cells is suppressed | [390] |
miRNA-145 | MMP-9 TP53 | Breast cancer | Apoptosis is induced Metastasis is inhibited | [391] |
miRNA-21-5p | ZNF367 | Breast cancer | Cancer cell invasion is suppressed by downregulation of ZNF367 | [392] |
miRNA-5100 | CXC12/CXCR4/EMT | Breast cancer | CXC12/CXCR4 axis is suppressed by miRNA-5100, which acts as a tumor suppressor EMT is inhibited, and cancer cell invasion and migration are decreased | [393] |
miRNA-3613-3p | SOCS2 | Breast cancer | Cancer cell proliferation and metastasis are enhanced SOCS2 is downregulated | [394] |
miRNA-423-5p | – | Breast cancer | The sensitivity of breast cancer cells to cisplatin is reduced | [395] |
miRNA-19b-3p | PTEN/EMT | Esophageal cancer | miRNA-19b-3p is upregulated EMT is induced by exosomal miRNA-19b-3p by downregulating PTEN Apoptosis is inhibited Growth and metastasis of cancer cells are enhanced | [396] |
miRNA-124 | EZH2 | Pancreatic cancer | Exosomal miRNA-124 is downregulated Apoptosis is induced, EMT is inhibited and cancer cell migration is decreased by miRNA-124 EZH2 is downregulated by miRNA-124 | [397] |
miRNA-21-5p miRNA-155-5p | BRG1 | Colon cancer | miRNA-21-5p and miRNA-155-5p are transferred from exosomes BRG1 expression is reduced M2 polarization of cancer cells is induced Cancer metastasis is enhanced | [398] |
miRNA-34c-3p | Integrin α2β1 | Non-small cell lung cancer | Metastasis and invasion of A549 cells are promoted by increased expression of integrins | [399] |
miRNA-7 | YAP | Lung cancer | YAP expression is inhibited and cancer cell sensitivity to gefitinib is increased | [400] |
miRNA-126a | – | Lung cancer | Secretion of exosomes by lung cancer cells is induced by exposure to doxorubicin Cancer cell migration and invasion are increased by exosomal miRNA-126a | [401] |
miRNA-122 | – | Hepatocellular carcinoma | Sensitivity of cancer cells to chemotherapy is increased by exosomal miRNA-122 | [402] |
miRNA-302b | ERK1/2 MMP-9 TGFβRII | Lung cancer | Cancer cell growth and invasion are inhibited ERK1/2, MMP-9, and TGFβRII are downregulated | [403] |
miRNA-21 | PDCD4 | Lung cancer | Lung cancer proliferation is increased Anti-tumor immunity is suppressed by the proliferation of myeloid-derived suppressor cells PDCD4 is downregulated | [404] |
miRNA-375 | ENAH | Esophageal cancer | Cancer progression is suppressed by decreasing the expression of ENAH | [405] |
miRNA-146b miRNA-222 | – | Papillary thyroid cancer | Proliferation of cancer cells is increased | [406] |
miRNA-200b | KLF6 | Ovarian cancer | KLF6 is downregulated by miRNA-200b M2 polarization of macrophages is induced | [407] |
miRNA-92b-3p | SOX4 | Ovarian cancer | Cancer progression is suppressed by inhibiting angiogenesis SOX4 is downregulated | [408] |
miRNA-224-5p | – | Renal cancer | Invasion and growth of cancer cells are suppressed | [407] |
miRNA-1228 | MMP-14 | Gastric cancer | Cancer progression is suppressed by downregulation of MMP-14 | [408] |
lncRNA ZFAS1 | Gastric cancer | – | Association with lymph node metastasis and TNM stage is observed EMT is induced Apoptosis is inhibited | [409] |
lncRNA KCNQ1OT1 | Colorectal cancer | miRNA-30a-5p/USP22/PD-L1 | Immune evasion is induced CD8 + T cell response is suppressed Expression of miRNA-30a-5p is decreased by acting as ceRNA USPP22 expression is upregulated to prevent PD-L1 ubiquitination PD-L1 expression is enhanced | [410] |
lncRNA HOTAIR | Breast cancer | ErB2 | A positive association is observed between HOTAIR and ErB2 HOTAIR expression is increased by ErB2 in a MAPK-dependent manner | [411] |
LINC01133 | Bladder cancer | Wnt | Low levels of LINC01133 in exosomes from bladder cancer cells are observed Wnt signaling is suppressed to impair cancer cell growth and metastasis | [412] |
Circ-ABCC1 | Colorectal cancer | Wnt/β-catenin | Cancer cell progression is enhanced by circ-ABCC1 via induction of β-catenin signaling | [376] |
Circ-0002130 | Non-small cell lung cancer | miRNA-498/HK2-GLUT1-LDHA | Cancer cell proliferation and invasion are increased in vitro and in vivo Osimertinib resistance is observed miRNA-498 is downregulated via sponging Expression of HK2, GLUT1, and LDHA is increased | [374] |
Circ-0008928 | Non-small cell lung cancer | miRNA-488/HK2 | Glycolysis, proliferation and cisplatin resistance of cancer cells are induced Expression of miRNA-488 is decreased to induce HK2 expression | (375) |