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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors

Fig. 1

STIE and TIME relationship. The anatomic and interactive relationship between TIME and STIE as well as key components of STIE are shown. STIE circulating in the blood and lymphatic vessels are in close contact with, and directly provide cell and molecular components to the tumor extracellular matrix which can be considered as part of TIME. The major cell and immune regulator components of STIE and TIME may vary with cancer type, examples of non-small cell lung cancer (NSCLC), hepatocellular carcinoma (HCC), and nasopharyngeal carcinoma (NPC) are summarized in Table 1. CC, cancer cell; CSC, cancer stem cell; Mac, Macrophage; DC, Dendritic cell; MDSC, myeloid-derived suppressor cells; NK, natural killer cells; IDO, Indoleamine 2,3-dioxygenase; Kyn, kynurenine; Trp, tryptophan

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Journal of Hematology & Oncology

ISSN: 1756-8722

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