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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors

Fig. 3

The functions of immune regulator IDO on STIE and TIME. Indoleamine 2,3-dioxygenase (IDO) has multiple roles on STIE and TIME. The detailed functions of IDO in different cells as shown by arrows. IDO1, which suppresses Teff cells and MDSC, mainly catalyzes the breakdown of tryptophan (Trp) to kynurenine (Kyn) in the DC: Dendritic cells, Treg, Activated T cells, and APC cells: Antigen-presenting cells. IDO2 catalyzes in B cells. Solid arrow: stimulation, Dashed arrow: possible stimulation; Vertical-horizontal line: suppression. IDO1 and IDO2 are two different enzymes, that catalyze the same reaction. MDSC: Myeloid-derived suppressor cell; Teff: Effector T cells; CAF: Cancer-associated fibroblast; TAM: Tumor-associated macrophage

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Journal of Hematology & Oncology

ISSN: 1756-8722

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