Fig. 6

Reshape STIE and TIME to prevent metastasis. This figure shows potential reshaping/targeting points to prevent systemic tumor progression, i.e., metastasis, starting from killing/removing tumors in situ in the primary site through radiotherapy/surgery. Upon the cancer metastasis, systemic therapy such as chemotherapy and immunotherapy are the mainstay treatment for these patients. Radiotherapy is frequently needed for either palliation or consolidation local therapy for good responder and palliation for symptoms for patients with disease progression. Single-cell transcriptomics and spatial transcriptomic techniques are useful to detect these therapeutic effects to uncover the underlying mechanism directly in patients. The red and green pipelines are representing blood vessels and lymphatic vessels which establish the connection between Tumor Immune Microenvironment (TIME) and Systemic Tumor Immune Environment (STIE)