Table 1 Major immune components of STIE and TIME

NSCLC

↑: CD8⁺ GranB⁺T, Naïve CD4⁺, CD4⁺NKT, Ter cell, NK, Cytolytic CD16⁺NK, CD14⁺ monocyte, basophil

-: Neutrophil, CD16⁺ monocyte

↓: CD8⁺PD-1⁺T, CD8⁺T CM, Treg, CD1c⁺DC, Macrophage, Eosinophil, Mast cell

↑: TGF-β1, IDO, Artemin, PD-1, PD-L1, CTLA-4, GITR, IL-17

↓: BMI1

↑: CD8⁺PD-1⁺ T, CD8⁺ T CM, Treg, Infiltrated CXCR3⁺NK, CD1c⁺DC

-: Naïve CD4⁺, Macrophage, CD14⁺monocyte, Neutrophil, Eosinophil

↓: CD8⁺ GranB⁺T, CD16⁺monocyte, NK, CD4⁺NKT, Cytolytic CD16⁺NK, Basophil, Mast cell

↑: TGF-β1, CTLA4, CD11c, CD14, CD39, ICOS, 41BB, IL-6, PPARγ

↓: IL-8, IL-1β, IFN-γ, Granzyme B, CD57, CD86, CD206

[29,30,31,32,33,34,35,36,37,38,39,40] [29]*

HCC

↑: Treg, MDSC

↓: CD8⁺ T, CD4⁺ T

↑: PD-L1, IL-6, LAYN

↓: PD-1, CTLA4, IFN-γ, LAG3, TIM3, PTPRO

↑: CD8⁺T, CD4⁺T, Treg, B cell, Monocyte, DC, Kupffer cell, Neutrophil

↓: NK, NKT

↑: PD-1, PD-L1, CTLA4, TIM3, LAG3, IFN-γ, IL-10, IgA

↓: CCL4, CCL14

[41,42,43,44,45,46,47,48,49,50,51,52,53,54,55]

NPC

↑: NK, PD-1⁺ NK

-: Treg

↓: CD8⁺T, CD4⁺T, B cell

↑: IL-2, IL-10, IL-18, MMP-9, CR1, IgM

↑: CD8⁺ T, Treg, B cell, PD-1⁺CXCR5⁻CD4⁺ Th-CXCL13,

CD19⁺ B cell

↓: NK

↑: PD-1, FOXP3, LAG3, HAVCR2, IFN-γ, IL2RA, IL-18, IL-21, CCL19, CCL20, CXCL10, CXCL13

[56,57,58,59,60,61,62,63,64,65]