Fig. 1
Kinetics of peripheral blood biomarkers and clinical outcome after CLL-1 CAR-T cell infusion. (A, B) Changes in patient body temperature and peripheral blood neutrophil numbers after CAR-T cell infusion, respectively. (C, D) Peripheral blood serum levels of IL-6, C-reactive protein (CRP) and ferritin before and after CAR-T cell infusion. (E) The ratio of CAR-T cells (CAR-T cells did not specifically distinguish between CD4 and CD8) to T cells in peripheral blood at various time periods. (F) Comparison of the peak values of CAR-T cells (CAR-T cells did not specifically distinguish between CD4 and CD8) in complete response (CR)/CRi and nonresponse (NR) patients. (G) Duration of response and survival after infusion of CLL-1 CAR-T cells. (H) Bone marrow smears of patient 4 and patient 6 before and after infusion. The data are expressed as the mean ± standard deviation (*p < 0.05)