Fig. 1
From: Emerging strategies to overcome resistance to third-generation EGFR inhibitors
Structure and functions of EGFR. A EGFR exon boundaries and associated extracellular, transmembrane, and intracellular protein domains. EGFR is involved in multiple signaling pathways and regulates numerous cell functions. B The tyrosine kinase domain of EGFR and the activation or inactivation of the catalytic domain. C EGFR domains and the molecular mechanisms of acquired resistance. The intracellular domain contains a juxtamembrane domain, tyrosine kinase domain, and multiple C-terminal tyrosine residues. Multiple mutations within the tyrosine kinase domain are associated with resistance and sensitivity to EGFR-TKIs