Fig. 5
From: Emerging strategies to overcome resistance to third-generation EGFR inhibitors
Chemical structures and structure–activity relationships of allosteric inhibitors. A The rational design of TERA-0236 (4), JBJ-02-112-05 (5), and JBJ-04-125-02 (6) and their inhibitory activities against EGFR. B X-ray cocrystal structure of EGFR with EAI001 (2) (PDB code: 5D41). C X-ray cocrystal structure of EGFR with EAI045 (3). D X-ray cocrystal structure of EGFR with EAI045 (in the active and inactive states) (PDB code: 5ZWJ). E X-ray cocrystal structure of EGFR with JBJ-04-125-02 (6) (PDB code: 6DUK)