Table 1 EGFR allosteric inhibitors

7, DDC4002 [100]

EGFR^L858R/T790M

IC₅₀ = 10 nmol/L

EGFR^{L858R/T790M/C797S}

IC₅₀ = 59 nmol/L

Phe856

8 [100]

EGFR^{L858R/T790M/C797S}

IC₅₀ = 19 nmol/L

Phe856

9 [100]

EGFR^{L858R/T790M/C797S}

IC₅₀ = 23 nmol/L

Phe856

10 [100]

EGFR^{L858R/T790M/C797S}

IC₅₀ = 13 nmol/L

Phe856

11 [100, 101]

EGFR^L858R/T790M

IC₅₀ = 1 nmol/L

EGFR^{L858R/T790M/C797S}

IC₅₀ = 5 nmol/L

Phe856

12 [100, 101]

EGFR^L858R/T790M

IC₅₀ = 3 nmol/L

EGFR^{L858R/T790M/C797S}

IC₅₀ = 4 nmol/L

Phe856